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6-AMINONICOTINIC ACID

SYNONYMS:

6-Aminopyridine-3-carboxylic Acid

 

 

 

 

 

 

CAS NO.:

3167-49-5

 

EINECS NO.:

221-630-4

 

FORMULA:

C6H7N2O2

 

H.S. CODE:

2933.39

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

1-0-0

 

DESCRIPTION:

Appearance:White solid powder ,Molecular Formula:139
Niacin (also called Nicotinic Acid) and Niacinamide (also called Nicotinamide), two compounds of water-soluble vitamin B complex, are active in the metabolism of body. Chemically they are 3-Pyridinecarboxylic acid and 3-Pyridinecarboxamide respectively. Commercially, niacin is obtained from beta -picoline or from quinoline, which are both obtainable from coal tar. Niacinamide, more water soluble, is the amide form of niacin. When an amide molecule attaches itself to niacin, it becomes niacinamide. The B vitamins niacin and niacinamide are known as preventives of pellagra. Niacin is interchangeable in metabolism with its amide, niacinamide. Nicotinamide is hydrolyzed to the acid in the digestive tract of non-ruminants. After absorption in the mucosa, the amide is formed again. In the rumen of ruminants, nicotinamide is converted in a short time to nicotinic acid. Nicotinamide and nicotinic acid are therefore equivalent in action in the case of farm animals. These are key ingredients in animal feed and animal feed premixes as these contribute to numerous metabolic reactions  as hydrogentransferring coenzymes.

 

APPLICATION

6-Aminonicotinic acid is used as an intermediate for agrochemcials, feed additives, pharmaceuticals and animal food enrichments. Niacin acts to reduce plasma cholesterol, as a vasodilator and to treat pellagra.  Niacin is used for the prophylaxis. Their derivatives are used for these effects.

SPECIFICATION & PACKING

appearance: WHITE CRYSTALLINE POWDER OR COLORLESS CRYSTAL

WATER: 0.5% MAX

MELTING POINT:  250 °C

PH VALUE: 7.5-8.0

RESIDUE ON IGNITION: 0.1% MAX

hEAVY METALS: 10PPM MAX

RELATED SUBSTANCE: 0.5% MAX

ASSAY: 98.5% - 101.5%
Packing: 20Kg/drum
Storage:
STORE IN A COOL, DRY PLACE: Keep tightly closed.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

MATERIAL SAFETY DATA SHEET

Section 1 - Chemical Product And Company Identification
MSDS Name:   6-Aminonicotinic Acid, 98%
Synonym:   6-Aminopyridine-3-Carboxylic Acid.

SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | % | EINECS# |
| 3167-49-5 |6-Aminonicotinic Acid | 98 | 221-630-4 |
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

SECTION 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:May cause eye irritation.
Skin:May cause skin irritation.
Ingestion:May cause irritation of the digestive tract. The toxicological
properties of this substance have not been fully investigated.
Inhalation:May cause respiratory tract irritation. The toxicological properties
of this substance have not been fully investigated.
Chronic:No information found.

SECTION 4 - FIRST AID MEASURES
Eyes:Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:Never give anything by mouth to an unconscious person. Get medical
aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and
drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:

SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

SECTION 7 - HANDLING and STORAGE
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage: Store in a tightly closed container. Store in a cool, dry,well-ventilated area away from incompatible substances.

SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.Exposure Limits
CAS# 3167-49-5:
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing:Wear appropriate protective clothing to prevent skin exposure.
Respirators:A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: > 300 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H6N2O2
Molecular Weight: 138.13

SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products:Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

SECTION 11 - TOXICOLOGICAL INFORMATION
RTECS#: CAS# 3167-49-5 unlisted.
LD50/LC50: Not available.
Carcinogenicity: 6-Aminonicotinic Acid -
Not listed by ACGIH, IARC, or NTP.

SECTION 12 - ECOLOGICAL INFORMATION
N/A

SECTION 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

SECTION 14 - TRANSPORT INFORMATION
IATA
:Not regulated as a hazardous material.
IMO
:Not regulated as a hazardous material.
RID/ADR
:Not regulated as a hazardous material.

SECTION 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where
possible).WGK (Water Danger/Protection)
CAS# 3167-49-5: No information available.
Canada
CAS# 3167-49-5 is listed on Canada's DSL List.
CAS# 3167-49-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
: CAS# 3167-49-5 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 

CERTIFICATION OF ANALYSIS

 

PRODUCT

6-AMINOCAPROIC ACID

BATCH NO.

070106

QUANTITY

3KGS

PACKING

3KGS/BAG

MANU. DATE

JAN.15,2007

EXPIRY DATE

JAN.16,2010

 

ITEMS

SPECIFICATION

RESULTS

APPEARANCE

WHITE CRYSTALLINE POWDER  OR COLORLESS CRYSTAL

 CONFORM

LOSS ON DRYING

=0.5%

0.22%

MELTING POINT

250?

COMPLIES

PH VALUE

7.5-8.0

7.8

RESIDUE ON IGNITION

=0.1%

0.03%

HEAVY METALS

=10PPM

CONFORM

RELATED SUBSTANCE

=0.5%

0.3%

ASSAY

98.5-101.5%

99.55%

 

CONCLUSION:THIS PRODUCT IS MEETS THE REQUIREMENTS OF USP28