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ACYCLOVIR

SYNONYMS:

2-Amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)
-6H-purin-6-one
;
Vipral; Virorax; Zovirax; Aciclovirum; Aciclovirum

 

 

CAS NO.:

59277-89-3

 

EINECS NO.:

261-685-1

 

FORMULA:

C8H11N5O3

 

H.S. CODE:

29339990

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

2-1-0-E

 

DESCRIPTION:

white to off-white crystalline powder.

Acyclovir is a partial nucleoside. It is a functional analog of the guanosine. Chemically acycloguanosine has an open-chain structure instead of the sugar ring. It is selectively and rapidly converted into the acyclo-guanosine monophosphate (acyclo-GMP) by highly affinitive thymidine kinase after administration in the cell. The monophosphate is further converted into diphosphate and into subsequently triphosphate by a number of cellular kinases. Acyclovir triphosphate terminates replication of herpes viral DNA.

 

APPLICATION

Acyclovir is a synthetic acyclic purine nucleoside analogue with selective antiviral activity predominantly against herpes simplex virus type I (HSV-1) and herpes simplex virus type II (HSV-2). Acyclovir is also active against varicella zoster virus (VZV), epstein-Barr virus (EBV) and cytomegalovirus (CMV) It is inactive against latent viruses in nerve ganglia. In addition to aciclovir (prodrug: valaciclovir)  antivirals against herpes simplex virus include cidofovir, docosanol, famciclovir, fomivirsen, foscarnet, ganciclovir, idoxuridine, penciclovir, trifluridine, tromantadine, valaciclovir, valganciclovir, and vidarabine  Valaciclovir is the prodrug which is converted to the active aciclovir in vivo by esterase.

SPECIFICATION & PACKING

APPEARANCE: white to off-white crystalline powder

IDENTIFICATION: to pass test A, B, C

ASSAY: 98.5 - 100.5%

ORGANIC IMPURITY: 1.0% max

HEAVY METALS: 10ppm max

GUANINE: 0.7% max

LOSS ON DRYING: 6.0% max
Packing:
Storage:
Keep container tightly closed. Keep container in a cool, well-ventilated area.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

MATERIAL SAFETY DATA SHEET
Section 1: Chemical Product and Company Identification

Product Name: Acyclovir

Catalog Codes: SLA4732

CAS#: 59277-89-3

RTECS: UP0791400

TSCA: TSCA 8(b) inventory: No products were found.

CI#: Not available.

Synonym: Zovirax, Aciclovir;9-[(2-Hydroxyethoxy)methyl]guanine; Acycloguanosine

Chemical Name: 6H-Purin-6-one,1,9-dihydro-2-amino-9-((2-hydroxyethoxy)methyl)-

Chemical Formula: C8-H11-N5-O3


Section 2: Composition and Information on Ingredients

Composition:

Name            CAS #              % by Weight

Acyclovir         59277-89-3            100

Toxicological Data on Ingredients: Acyclovir: ORAL (LD50): Acute: >20000 mg/kg [Rat]. >10000 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.

MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.

Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention.

Skin Contact:

In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Serious Inhalation: Not available.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat.

Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Slightly explosive in presence of open flames and sparks.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion hazard.

Section 6: Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:

Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection:

Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (crystalline powder.)

Odor: Not available.

Taste: Not available.

Molecular Weight: 225.2 g/mole

Color: White. Off-white.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: 257°C (494.6°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: Not available.

Solubility:

Very slightly soluble in cold water, methanol.

Solubility in Water: 1.3mg/ml

Solubility in Methanol: 0.2mg/ml

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, excess dust generation.

Incompatibility with various substances: Not available.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): >10000 mg/kg [Mouse].

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.

MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells.

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects and birth defects (teratogenic).

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: May cause skin irritation.

Eyes: May cause eye irritation.

Inhalation: May cause respiratory tract irritation.

Ingestion: May cause gastrointestinal tract irritation with abdominal pain, nausea, vomiting, diarrhea or decreased motility or constipation. May affect behavior/central nervous system(hallucinations, convulsions, muscle contraction or spasticity, somnolence, dizziness, vertigo, headache, lethargy, tremors, confusion, seizures,delirium, jitters, lightheadedness, obtundation, fatigue, insomnia, irritability, mental depression, antipsychotic, coma), brain, respiratory system (sputum), blood (agranulocytosis, thrombocytopenia, leukopenia, thromocytosis,lymphopenia), urinary system (kidney failure, acute tubular necrosis). Other symptoms may include sore throat,thirst, muscle cramps, perspiration, fever, lymphadenopathy, substernal burning sensation, leg pain, hematuria,hypotension, heart palpitation, bone marrow hypoplasia. May cause allergic dermatits with urticaria or rash, acne Chronic Potential Health Effects:
Ingestion: Prolonged or repeated ingestion may affect the urinary system, and metabolism (anorexia).

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental

control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: No products were found.

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):

R36/38- Irritating to eyes and skin.

R40- Possible risks of irreversible effects.

S2- Keep out of the reach of children.

S36/37- Wear suitable protective clothing and gloves.

S46- If swallowed, seek medical advice

immediately and show this container or label.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an approved/certified respirator or equivalent.Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

CERTIFICATION OF ANALYSIS