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 CARBAMAZEPINE

SYNONYMS:

Carbamezapine; Carbazepine;
5-carbamoyl-5H-dibenz[b,f]azepine; 5H-Dibenz[b,f]azepine-5-carboxamide;
Amizepin; Neurotol; Tegretol.

 

 

CAS NO.:

298-46-4

 

EINECS NO.:

206-062-7

 

FORMULA:

C15H12N2O

 

H.S. CODE:

N/A

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

1-0-0-A

 

DESCRIPTION:

white to off-white powder

 

APPLICATION

Carbamazepine is a primary or secondary anticonvulsant agent drug  to treat certain forms of epilepsy and specific analgesic to relieve pain associated with trigeminal neuralgia and phantom limb.

SPECIFICATION & PACKING

APPEARANCE: white to off-white powder

BIBLIOGRAPHY: BP98, USP24
Packing:
20kgs in fiber drum

Storage: Store in a cool, dry place. Store in a tightly closed container.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

Section 1 - Chemical Product And Company Identification
MSDS Name:   Carbamazepine, 99%
Synonym:   Amizepin; Neurotol; Tegretol.

SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | % | EINECS# |
| 298-46-4 |Carbamazepine | 99% | 206-062-7 |
Hazard Symbols: XN
Risk Phrases: 22 42/43

SECTION 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. May cause sensitization by inhalation and skin contact.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:May cause eye irritation.
Skin:May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract.
May cause liver and kidney damage. The toxicological properties of  this substance have not been fully investigated.
Inhalation:May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:May cause liver and kidney damage. Adverse reproductive effects have been reported in humans. Prolonged or repeated exposure may cause sensitization in certain sensitive individuals.

SECTION 4 - FIRST AID MEASURES

Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

SECTION 5 - FIRE FIGHTING MEASURES
General Information:As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:Use water spray, dry chemical, carbon dioxide, or chemical foam.

SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

SECTION 7 - HANDLING and STORAGE
Handling:Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust,vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation.
Storage:Store in a cool, dry place. Store in a tightly closed container.

SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 298-46-4:
Personal Protective Equipment
Eyes:Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:Wear appropriate protective gloves to prevent skin exposure.
Clothing:Wear appropriate protective clothing to prevent skin exposure.
Respirators:Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 191 - 192 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: practically insoluble in water
Specific Gravity/Density:
Molecular Formula: C15H12N2O
Molecular Weight: 236.0968

SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:Stable under normal temperatures and pressures.
Conditions to Avoid:Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Oxidizing agents.Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

SECTION 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 298-46-4: HN8225000
LD50/LC50:
CAS# 298-46-4: Oral, mouse: LD50 = 529 mg/kg; Oral, rabbit: LD50 =
2680 mg/kg; Oral, rat: LD50 = 1957 mg/kg.
Carcinogenicity:
Carbamazepine -
Not listed by ACGIH, IARC, or NTP.
Other:See actual entry in RTECS for complete information.

SECTION 12 - ECOLOGICAL INFORMATION
N/A

SECTION 13 - DISPOSAL CONSIDERATIONS

Dispose of in a manner consistent with federal, state, and local regulations.

SECTION 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

SECTION 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:R 22 Harmful if swallowed.
R 42/43 May cause sensitization by inhalation and skin contact.
Safety Phrases:S 22 Do not breathe dust.
S 24 Avoid contact with skin.
S 27 Take off immediately all contaminated clothing.
WGK (Water Danger/Protection)
CAS# 298-46-4: No information available.
Canada
CAS# 298-46-4 is listed on Canada's DSL List.
CAS# 298-46-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 298-46-4 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 10/18/1999 Revision #3 Date: 5/07/2002

CERTIFICATE OF ANALYSIS