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 DIETHYLSTILBESTROL

SYNONYMS:

DES; 4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol

 

 

CAS NO.:

56-53-1

 

EINECS NO.:

200-278-5

 

FORMULA:

C18H20O2

 

H.S. CODE:

N/A

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

1-1-0-E

 

DESCRIPTION:

Clear to slightly hazy colorless to faint yellow solution at 100mg/ml in methanol.

 

APPLICATION

Synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone

SPECIFICATION & PACKING

CHARACTERISTICS:THE COLOURLESS CRYSTAL,EITHER THE WHITE CRYSTAL POWDERS

IDENTIFICATION:      POSITIVE

ACID BASICITY:       NEUTRALITY IS REACTED

MONO-AND DIMETHYL ETHERS:  COMPLIES

4,4-DIHYDROXYSTIBENE

AND RELATED ETHERS:  325nm  A≤0.50

ORGANIC VOLATILE IMPURITIES: COMPLIES

MELTING POINT:     169~175?

LOSS ON DRYING:   0.5%MAX.

SULPHATED ASH:    0.1%MAX.

ASSAY:              97.0~100.5% (C18H20O2)
Packing:1g,5g,25g,100g,etc.

Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Carcinogenic, eratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

Section 1: Chemical Product and Company Identification

Product Name: Diethylstilbestrol

CAS#: 56-53-1

Synonym: DES; 4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol

Chemical Name: Not available.

Chemical Formula: C18H20O2


Section 2: Composition and Information on Ingredients

Composition:

Name                  CAS #           % by Weight

Diethylstilbestrol        56-53-1                 100

Toxicological Data on Ingredients: Diethylstilbestrol LD50: Not available. LC50: Not available.

Section 3: Hazards Identification

Potential Acute Health Effects:

Very hazardous in case of ingestion. Hazardous in case of skin contact (permeator). Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.

Potential Chronic Health Effects:

Very hazardous in case of ingestion.

Hazardous in case of skin contact (permeator).

Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.

CARCINOGENIC EFFECTS: Classified 1 (Known.) by NTP.

MUTAGENIC EFFECTS: Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: PROVEN

The substance is toxic to the reproductive system.

Repeated or prolonged exposure to the substance can produce target organs damage.

 

Section 4: First Aid Measures

Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used.

Skin Contact:

After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.

Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated

clothing before reusing.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical

attention.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation: Not available.

Ingestion:

Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not

breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.

Serious Ingestion: Not available.

 

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Material in powder form, capable of creating a dust explosion.

Special Remarks on Explosion Hazards: Not available.

 

Section 6: Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by

spreading water on the contaminated surface and dispose of according to local and regional authority

requirements.

Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

 

Section 7: Handling and Storage

Precautions:

Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,

evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with skin Wear suitable protective clothing If you feel unwell, seek medical attention and show the label when possible.

Storage:

Keep container dry. Keep in a cool place. Ground all equipment containing material. Carcinogenic, eratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room.

 

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available.

 

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid powder.)

Odor: Not available.

Taste: Not available.

Molecular Weight: 268.34 g/mole

Color: White.

pH (1% soln/water): Not available.

Boiling Point: Decomposes.

Melting Point: 171°C (339.8°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol, diethyl ether.

Solubility:

Soluble in methanol, diethyl ether.

Very slightly soluble in cold water.

 

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: No.

 

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Ingestion.

Toxicity to Animals:

LD50: Not available.

LC50: Not available.

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: Classified 1 (Known.) by NTP.

DEVELOPMENTAL TOXICITY: PROVEN

The substance is toxic to the reproductive system.

Other Toxic Effects on Humans:

Very hazardous in case of ingestion.

Hazardous in case of skin contact (permeator).

Slightly hazardous in case of skin contact (irritant), of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.

 

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are more toxic.

Special Remarks on the Products of Biodegradation: Not available.

 

Section 13: Disposal Considerations

Waste Disposal:

 

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:

Diethylstilbestrol

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause cancer which would require a warning under the statute: Diethylstilbestrol

TSCA 8(b) inventory: Diethylstilbestrol

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

DSCL (EEC): R45- May cause cancer.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator

when ventilation is inadequate.

Safety glasses.

 

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

CERTIFICATE OF ANALYSIS

PRODUCT

DIETHYLSTILBESTROL

STANDARD

BP/USP

BATCH NO.

20080901

MANUFACTURE DATE

SEPT.15,2008

QUANTITY

2KGS

EXPIRY DATE

SEPT.14,2011

PACKING

2KGS/BAG

REPORT DATE

SEPT.16,2008

 

ITEMS

SPECIFICATION

RESULTS

CHARACTERISTICS

THE COLOURLESS CRYSTAL,EITHER THE WHITE CRYSTAL POWDERS

COMPLIES

IDENTIFICATION

POSITIVE

COMPLIES

ACID BASICITY

NEUTRALITY IS REACTED

COMPLIES

4,4-DIHYDROXYATIBENE AND

RELATED ETHERS

A≤0.5%

COMPLIES

MELTING POINT

169-172?

169-172?

LOSS ON DRYING

=0.5%

0.4%

SULPHATED ASH

=0.1%

0.05%

ASSAY

98% MIN

99.5%

ORGANIC VOLATILE IMPURITIES

COMPLIES

COMPLIES

 

CONCLUSION:CONFORM WITH THE BP1998/USP26 STANDARD