Safety Data Sheets of Ethyl Acetoacetate
Section 1: Chemical ProductProduct Name: Ethyl acetoacetate
Synonym: 3-Oxobutanoic acid ethyl ester
Chemical Formula: C6H10O3
2: Composition and Information on Ingredients
Toxicological Data on Ingredients: Ethyl acetoacetate: ORAL (LD50):
Acute: 3980 mg/kg [Rat]. 5105 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects: Hazardous in case of skin contact
(irritant, permeator), of eye contact (irritant), of ingestion,
Potential Chronic Health Effects:
Hazardous in case of skin contact (irritant, permeator), of eye
contact (irritant), of ingestion, of inhalation.
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Section 4: First Aid Measures
Check for and remove any contact lenses. Immediately flush eyes
with running water for at least 15 minutes, keeping eyelids open.
Cold water may be used. Do not use an eye ointment. Seek medical
After contact with skin, wash immediately with plenty of water.
Gently and thoroughly wash the contaminated skin with running
water and non-abrasive soap. Be particularly careful to clean
folds, crevices, creases and groin. Cold water may be used. Cover
the irritated skin with an emollient. If irritation persists,
seek medical attention. Wash contaminated clothing before reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin
with an anti-bacterial cream. Seek medical attention.
Inhalation: Allow the victim to rest in a well ventilated area.
Seek immediate medical attention.
Evacuate the victim to a safe area as soon as possible. Loosen
tight clothing such as a collar, tie, belt or waistband. If breathing
is difficult, administer oxygen. If the victim is not breathing,
perform mouth-to-mouth resuscitation. Seek medical attention.
Do not induce vomiting. Loosen tight clothing such as a collar,
tie, belt or waistband. If the victim is not breathing, perform
mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Combustible.
Auto-Ignition Temperature: 295¡ãC (563¡ãF)
Flash Points: CLOSED CUP: 57¡ãC (134.6¡ãF).
OPEN CUP: 84.4¡ãC (183.9¡ãF).
Flammable Limits: LOWER: 1.4% UPPER: 9.5%
Products of Combustion: These products are carbon oxides (CO,
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact:
Risks of explosion of the product in presence of static discharge:
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Dilute with water and mop up, or absorb with an inert dry material
and place in an appropriate waste disposal container.
Keep away from heat. Keep away from sources of ignition. Stop
leak if without risk.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground
all equipment containing material. Do not ingest. Do not breathe
gas/fumes/ vapour/spray. Wear suitable protective clothing In
case of insufficient ventilation, wear suitable respiratory equipment
If ingested, seek medical advice immediately and show the container
or the label. Avoid contact with skin and eyes
Flammable materials should be stored in a separate safety storage
cabinet or room. Keep away from heat. Keep away from sources of
ignition. Keep container tightly closed. Keep in a cool, well-ventilated
place. Ground all equipment containing material. Keep container
dry. Keep in a cool place.
Section 8: Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep
the airborne concentrations of vapors below their respective threshold
limit value. Ensure that eyewash stations and safety showers are
proximal to the work-station location.
Splash goggles. Lab coat. Vapor respirator. Be sure to use an
approved/certified respirator or equivalent.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A
self contained breathing apparatus should be used to avoid inhalation
of the product. Suggested protective clothing might not be sufficient;
consult a specialist BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Taste: Not available.
Molecular Weight: 130.16 g/mole
pH (1% soln/water): Not available.
Boiling Point: 180.8¡ãC (357.4¡ãF)
Melting Point: 4.27¡ãC (39.7¡ãF)
Critical Temperature: Not available.
Specific Gravity: 1.03 (Water = 1)
Vapor Pressure: 0.8 mm of Hg (@ 20¡ãC)
Vapor Density: 4.48 (Air = 1)
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water)
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility: Partially soluble in cold water.
10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
11: Toxicological Information
Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 3980 mg/kg [Rat].
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans: Hazardous in case of skin contact
(irritant, permeator), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely.
However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation
are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
13: Disposal Considerations
14: Transport Information
DOT Classification: CLASS 3: Combustible liquid with a flash point
greater than 37.8C (100F).
Identification: : Flammable liquids n.o.s. : UN1993 PG: Not available.
Special Provisions for Transport: No DOT, ref 49CFR, 173.150
15: Other Regulatory Information
Federal and State Regulations:
Pennsylvania RTK: Ethyl acetoacetate
Massachusetts RTK: Ethyl acetoacetate
TSCA 8(b) inventory: Ethyl acetoacetate
Other Regulations: OSHA: Hazardous by definition of Hazard Communication
Standard (29 CFR 1910.1200).
CLASS B-3: Combustible liquid with a flash point between 37.8¡ãC
(100¡ãF) and 93.3¡ãC
DSCL (EEC): R36/38- Irritating to eyes and skin.
Health Hazard: 2
Fire Hazard: 2
Personal Protection: h
National Fire Protection Association (U.S.A.):
Vapor respirator. Be sure to use an approved/certified respirator
or equivalent. Wear appropriate respirator when ventilation is
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.