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NORFLOXACIN

SYNONYMS:

Noroxin; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-
(1-piperazinyl)-3-quinolinecarboxylic acid; Norfloxacino; Norfloxacine;

 

 

CAS NO.:

70458-96-7

 

EINECS NO.:

274-614-4

 

FORMULA:

C16H18FN3O3

 

H.S. CODE:

30049090

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

1-1-0

 

DESCRIPTION:

off-white to yellow crystals.

 

APPLICATION

Norfloxacin, the second generation drug of the quinolone antibiotics, is the virus reverse transcriptase inhibitor.

SPECIFICATION & PACKING

APPEARANCE: white to off-white crystals

IDENTIFICATION: Complies Test A,B

ASSAY: 98.0% min

LOSS ON DRYING: 1.0% max

RELATED SUBSTANCE: 0.5% max

HEAVY METALS: 15ppm max

SULFATED ASH: 0.5% max
Packing:
25kgs in fiber drum

Storage: Store in original container in a cool dark place.

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

CHEMICAL INDENTIFICATION

Product Name NORFLOXACIN 

Synonyms : Noroxin; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Norfloxacino; Norfloxacine;

 

COMPOSITION/INFORMATION ON INGREDIENTS

C.A.S. No 70458-96-7 

Molecular Formula : C16H18FN3O3

Formula Weight: 319.33 

 

HAZARDS IDENTIFICATION

Not considered hazardous when handled under normal conditions with good house keeping.

Label precautionary statements:


FIRST-AID MEASURES

In case of inhalation:

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

In case of contact with skin:

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

In case of contact with eyes:

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

In case of ingestion:

If swallowed, wash out mouth with water, provided person is concious. Seek medical advice.

Remove and wash/dispose of contaminated clothing promptly.

FIRE FIGHTING MEASURES

Extinguishing Media:

Carbon dioxide, dry chemical powder or appropriate foam. Water spray.

Unusual fire and explosion hazards:

Emits toxic fumes under fire conditions

Special fire fighting procedures:

Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.


ACCIDENTAL RELEASE MEASURES

Ensuring personal safety, mark out contaminated area with signs and prevent unauthorised access. Turn leaking containers up to prevent further Evaculate area. Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves. Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pick-up complete.

 

HANDLING AND STORAGE

Store in original container in a cool dark place.

 

EXPOSURE CONTROL/PERSONAL PROTECTION

Respiratory protection:

required when dusts are generated.

Eye protection:

required.

Hand protection:

required.

Industrial hygiene:

Immediately change contaminated clothing. Wash hands and face after working with substance.

 

PHYSICAL AND CHEMICAL PROPERTIES

Appearance 

Odour 

Melting Point 

Solubility 

 

STABILITY AND REACTIVITY

Conditions to be avoided:

Unknown

Substances to be avoided:

Unknown

Hazardous decomposition products:

Unknown

TOXICOLOGICAL INFORMATION

N/A

ECOLOGICAL INFORMATION

Do not allow product to enter drinking water supplies, waste water or soil!

 

DISPOSAL CONSIDERATIONS

Dissolve or mix material with a suitable combustible solvent and incinerate in a chemical incinerator equipped with an afterburner and scrubber.

Material should be disposed of in keeping with all local and national legislation. Packaging should be disposed of in keeping with all local and national legislation. Handle contaminated containers as product.

 

TRANSPORT INFORMATION

Classification:  N/A

UN Number:  N/A

 

REGULATORY INFORMATION

N/A

 

OTHER INFORMATION

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.S

SPECIAL DESCRIPTION

Fluoroquinolones belong to a group of synthetic antibiotics that are derived from basic structure of nalidixic acid and have substituents at N-1, C-5, C-7, position 8 and a fluorine atom at position 6. There are also polycyclic derivatives. Quinolone antibiotics have a ketone at position 4 and a carboxylic group at position 3. Fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, resulting the inhibition of DNA replication and transcription. Fluorine at position 6 enhances gyrase inhibition and cell penetration. Piperaziny substituents provide activity against Gram-negative bacteria and pyrrolidinyl moiety is active against Gram-positive cocci. They improve water solubility needed oral application. The function substituted at position 8 IS to control anaerobe activity.
 

Fluoroquinolone

Substituent

Substituted at N-1

 

Norfloxacin

Ethyl

Enoxacin

Ethyl

Lomefloxacin

Ethyl

Fleroxacin

Fluoro ethyl

Difloxacin

Fluorophenyl

Temafloxacin

Difluorophenyl

Trovafloxacin

Difluorophenyl

Amifloxacin

Methyl amino

Ciprofloxacin

Cyclopropyl

Grepafloxacin

Cyclopropyl

Alumofloxacin

Cyclopropyl

Gemifloxacin

Cyclopropyl

Moxifloxacin

Cyclopropyl

Ecenofloxacin

Cyclopropyl

Balofloxacin

Cyclopropyl

Substituted at C-5

 

Sparfloxacin

Amine

Grepafloxacin

Methyl

Substituted at C-7

 

Trovafloxacin

Bicyclic

Moxifloxacin

Bicyclic

Danafloxacin

Bicyclic

Garenoxacin

Bicyclic

Ciprofloxacin

Piperazinyl

Lomefloxacin

Piperazinyl

Norfloxacin

Piperazinyl

Fleroxacin

Piperazinyl

Ofloxacin

Piperazinyl

Sparfloxacin

Piperazinyl

Grepafloxacin

Piperazinyl

Gatafloxacin

Piperazinyl

Levofloxacin

Piperazinyl

Clinafloxacin

Pyrrolidinyl

Nadifloxacin

Pyrrolidinyl

Sitafloxacin

Pyrrolidinyl

Irloxacin

Pyrryl

Balofloxacin

Piperidinyl

Substituted at position 8

 

Sparfloxacin

F

Lomefloxacin

F

Fleroxacin

F

Ciprofloxacin

CH2

Temafloxacin

CH2

Pefloxacin

CH2

Norfloxacin

CH2

Grepafloxacin

CH2

Clinafloxacin

Cl

Sitafloxacin

Cl

Enoxacin

N

Tosufloxacin

N

Gemifloxacin

N

Trovafloxacin

N

Ecenofloxacin

N

Alatrofloxacin

N

Gatifloxacin

Methoxy

Pazufloxacin

Methoxy

Balofloxacin

Methoxy

Moxifloxacin

Methoxy

Garenoxacin

Methoxy

Tricyclic derivatives

 

Abufloxacin

 

Droxacin

 

Flumequine

 

Levofloxacin

 

Marbofloxacin

 

Miloxacin

 

Ofloxacin

 

Oxolinic acid

 

Pazufloxacin

 

Prulifloxacin

 

Rufloxacin

 

Verbafloxacin

 

Norfloxacin, the second generation drug of the quinolone antibiotics, is the virus reverse transcriptase inhibitor

CLINICAL APPLICATIONS;
-Uncomplicated urinary tract infections
-Complicated urinary tract infections
-Pyelonephritis
-sexually transmitted diseases
-prostatitis
-skin and tissue infections
-Urethral and cervical gonococcal infections