Acetaminophen,4-Acetamidophenol; APAP; N-Acetyl-p-aminophenol; 4'-Hydroxyacetanilide; N-(4-Hydroxyphenyl)acetamide

























Acetaminophen is an odorless, slightly bitter taste white crystalline powder. It is soluble in organic solvents such as methanol and ethanol but slightly soluble in water and ether. It's pH range is 5.5 - 6.5 based on saturated aqueous solution.



Paracetamol (para-acetyl-amino-phenol) is another name of acetaminophen (N-acetyl-para-aminophenol). It is also used as an intermediate for pharmaceuticals(as a precursor in penicillin) and azo dyes, stabilizer for hydrogen peroxide, photographic chemicals.



APPEARANCE: white crystalline powder


ASSAY: 99.0-101.0% 

MELTING POINT: 168 - 172 C

HEAVY METAL: 10ppm max

P-AMINOPHENOL: 50ppm max


LOSS ON DRYING: 0.5% max

CHLORIDE: 0.014% max

SULFATE: 0.02% max

SULFIDE: pass test

READILY CARBONIZABALES: pass test (4-chloroacetanilide)
Packing: 25KG/BAG

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.








Section 1: Chemical Product and Company Identification

Product Name: Acetaminophen,Paracetamol

CAS#: 103-90-2

Synonym: Paracetamol; N-(4-Hydroxyphenyl)acetamide

Chemical Formula: C8H9NO2

Section 2: Composition and Information on Ingredients


Name               CAS # %         by Weight

Acetaminophen    103-90-2             100

Toxicological Data on Ingredients: Not applicable.

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.

Potential Chronic Health Effects:





Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.


If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Serious Inhalation: Not available.


Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an

unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by

spreading water on the contaminated surface and dispose of according to local and regional authority


Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage


Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the

residue under a fume hood. Ground all equipment containing material. Do not breathe dust.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.


Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid.

Odor: Not available.

Taste: Not available.

Molecular Weight: 151.17 g/mole

Color: Not available.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: 170°C (338°F)

Critical Temperature: Not available.

Specific Gravity: 1.293 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: Not available.

Solubility: Not available.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Not available.

Toxicity to Animals:

LD50: Not available.

LC50: Not available.

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Excreted in maternal milk in human.

Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are more toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Acetaminophen

Other Regulations: Not available.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).


This product is not classified according

to the EU regulations.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:


Lab coat.

Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.


PARACETAMOL, chemically N-(4-Hydroxyphenyl) acetamide, is derived from the interaction of p-aminophenol and an aqueous solution of acetic anhydride. Acetaminophen is a nonprescription analgesic and antipyretic drug similar to aspirin. But acetaminophen is not an NSAID (Nonsteroidal Antiinflammatory Drug) as it doesn't participate in the inflammatory response. But acetaminophen is not an NSAID as it doesn't participate in the inflammatory response as it can not inhibit cyclooxygenases in the presence of peroxides. There are high levels of peroxides in platelets. Prostaglandin which reduces blood coagulation is produced through cyclooxygenase pathway. In result, NSAIDs including aspirin have detrimental effects on the stomach lining, where prostaglandins serve a protective role, but paracetamol has almost no adverse effects on the stomach or esophagus. Taking large doses of acetaminophen for a long time may impair liver function to some liver damage.
Nonsteroidal Antiinflammatory Drugs (NSAIDs); chemically heterogeneous large groups of drugs which suppress inflammation in a manner similar to steroids, but less side effects of sedation, respiratory depression, or addiction than steroids. They are widely used for the treatment of inflammatory disorders and painful conditions such as rheumatoid arthritis, gout, bursitis, painful menstruation, and headache. They are effective in the relief of pain and fever. NSAIDs inhibit the cyclooxygenase (COX) activity resulting in decreased synthesis of prostaglandin, leukotriene and thromboxane precursors such as the ubiquitous enzyme which catalyzes the initial step in the synthesis of prostanoids. Prostanoid is any of a group of C-20 fatty acids complex with an internal five or six carbon rings such as prostaglandins, prostanoic acid, prostacyclins, and thromboxane; derived from arachidonic acid (C-20 polyunsaturated fatty acid with four cis double bonds). The action or the synthesis of prostanoids are involved in the modulation of a variety of pathophysiologic processes including inflammation, hemostasis, thrombosis, cytoprotection,  ulceration, hemodynamics and other the progression of kidney diseases. Thus, NSAIDs as non-selective inhibitors of the cyclooxygenases (both the cyclooxygenase-1 and cyclooxygenase-2 isoenzymes) may have beneficial as well as untoward effects on a variety of human diseases. Low stomach prostanoid levels caused by COX-1 inhibitors can result in ulceration and internal bleeding and perforation. The selective COX-2 inhibitors such as oxicam, meloxicam, and coxibs (celecoxib, rofecoxib, valdecoxib, parecoxib and etoricoxib) do not interfere with COX-1. The most prominent NSAID is aspirin. Nonaspirin NSAIDs can be classified based on chemical structures.

Nonsteroidal Anti-Inflammatory Drugs (NSAID) by chemical structure