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 VALACICLOVIR HYDROCHLORIDE

SYNONYMS:

Zelitrex; Talavir; Valtrex; Virval; Acyclovir-valine; L-Valine 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride; L-Valine ester 9-((2-hydroxyethoxy)methyl)guanine monohydrochloride; Valaciclovir hydrochloride; 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate monohydrochloride; Developm;

 

 

CAS NO.:

124832-27-5

 

EINECS NO.:

N/A

 

FORMULA:

C13H20N6O4·HCl

 

H.S. CODE:

3002 Human or Animal Blood, Antisera and Other Blood Fractions, Vaccines, Toxins

 

CLASS NO.:

N/A

 

UN NO.:

N/A

 

NFPA:

N/A

 

DESCRIPTION:

white to off-white crystalline powder.
Acyclovir is a partial nucleoside. It is a functional analog of the guanosine. Chemically acycloguanosine has an open-chain structure instead of the sugar ring. It is selectively and rapidly converted into the acyclo-guanosine monophosphate (acyclo-GMP) by highly affinitive thymidine kinase after administration in the cell. The monophosphate is further converted into diphosphate and into subsequently triphosphate by a number of cellular kinases. Acyclovir triphosphate terminates replication of herpes viral DNA.

 

APPLICATION

Acyclovir is a synthetic acyclic purine nucleoside analogue with selective antiviral activity predominantly against herpes simplex virus type I (HSV-1) and herpes simplex virus type II (HSV-2). Acyclovir is also active against varicella zoster virus (VZV), epstein-Barr virus (EBV) and cytomegalovirus (CMV) It is inactive against latent viruses in nerve ganglia. In addition to aciclovir (prodrug: valaciclovir)  antivirals against herpes simplex virus include cidofovir, docosanol, famciclovir, fomivirsen, foscarnet, ganciclovir, idoxuridine, penciclovir, trifluridine, tromantadine, valaciclovir, valganciclovir, and vidarabine  Valaciclovir is the prodrug which is converted to the active aciclovir in vivo by esterase.The product is used as anti-virus medicament.

SPECIFICATION & PACKING

APPEARANCE: white to off-white crystalline powder

IDENTIFICATION: to pass test A, B, C

ASSAY: 98.5 - 100.5%

RELATED MATTERS: 2.0% max

HEAVY METALS: 10ppm max

OPTICAL ROTATION: -8.5º  ~ -11.5º

RESIDUE ON IGNITION: 0.1% max

ACYCICLOVIR: 1.5% max

LOSS ON DRYING: 8.0% max
Packing:
25kg cardboard drum lined with 2-ply PE bags

Storage: stored in tightly-closed container at room. Protect from moisture

RAW MATERIAL:

N/A

END GOODS:

N/A

REMARKS:

N/A

MATERIAL SAFE DATA SHEETS

CHEMICAL INDENTIFICATION

Product Name: VALACICLOVIR HYDROCHLORIDE 

Synonyms : Zelitrex; Talavir; Valtrex; Virval; Acyclovir-valine; L-Valine 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride; L-Valine ester 9-((2-hydroxyethoxy)methyl)guanine monohydrochloride; Valaciclovir hydrochloride; 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate monohydrochloride; Developm;

 

COMPOSITION/INFORMATION ON INGREDIENTS

C.A.S. No 124832-27-5 

Molecular Formula C13H20N6O4.HCl 

Formula Weight 360.80 

Merck Index 13:9966 

Product Group Antiviral 

 

HAZARDS IDENTIFICATION

Not considered hazardous when handled under normal conditions with good house keeping.

Label precautionary statements:

S36/37 Wear suitable protective clothing and gloves. 

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed. 

 

FIRST-AID MEASURES

In case of inhalation:

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

In case of contact with skin:

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

In case of contact with eyes:

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

In case of ingestion:

If swallowed, wash out mouth with water, provided person is concious. Seek medical advice.

Remove and wash/dispose of contaminated clothing promptly.

FIRE FIGHTING MEASURES

Extinguishing Media:

Carbon dioxide, dry chemical powder or appropriate foam. Water spray.

Unusual fire and explosion hazards:

Emits toxic fumes under fire conditions

Special fire fighting procedures:

Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

 

ACCIDENTAL RELEASE MEASURES

Ensuring personal safety, mark out contaminated area with signs and prevent unauthorised access. Turn leaking containers up to prevent further Evaculate area. Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves. Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pick-up complete.

 

HANDLING AND STORAGE

Store under the following conditions: Store cool, dark and dry.

 

EXPOSURE CONTROL/PERSONAL PROTECTION

Respiratory protection:

required when dusts are generated.

Eye protection:

required.

Hand protection:

required.

Industrial hygiene:

Immediately change contaminated clothing. Wash hands and face after working with substance.

 

PHYSICAL AND CHEMICAL PROPERTIES

Appearance White powder

Odour None

Melting Point 

Solubility Soly in water.

 

STABILITY AND REACTIVITY

Conditions to be avoided:

Unknown

Substances to be avoided:

Unknown

Hazardous decomposition products:

Unknown

 

TOXICOLOGICAL INFORMATION

N/A

ECOLOGICAL INFORMATION

Do not allow product to enter drinking water supplies, waste water or soil!

 

DISPOSAL CONSIDERATIONS

Dissolve or mix material with a suitable combustible solvent and incinerate in a chemical incinerator equipped with an afterburner and scrubber.

Material should be disposed of in keeping with all local and national legislation. Packaging should be disposed of in keeping with all local and national legislation. Handle contaminated containers as product.

 

TRANSPORT INFORMATION

Classification:  N/A

UN Number:  N/A

 

REGULATORY INFORMATION

N/A

 

OTHER INFORMATION

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.

SPECIAL DESCRIPTION